TRYPANOCIDAL ACTION OF PHENANTHRIDINE COMPOUNDS: FURTHER 2:7-DIAMINO PHENANTHRIDINIUM COMPOUNDS
نویسندگان
چکیده
منابع مشابه
comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اول2-Phenylaminonaphthoquinones and related compounds: synthesis, trypanocidal and cytotoxic activities.
A series of new 2-aminonaphthoquinones and related compounds were synthesized and evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited epimastigote growth and trypomastigote viability. Several compounds showed similar or higher activity and selectivity as compared with current trypanocidal drug, nifurtimox. Compound 4l exhibit higher selectivity than nifurtim...
متن کاملFurther water solubility determinations of insecticidal compounds.
The aqueous solubility of 39 insecticidal and related compounds was determined at 20 +/- 1.5 degrees C, using a previously described shaking and centrifugation method. Fenamiphos, fenthion and methidathion produced values substantially less than those reported in the literature whereas, aminocarb, diazinon, dicapthon, pirimiphos-ethyl and pirimiphos-methyl gave solubilities substantially greate...
متن کاملA new synthetic approach to 6-unsubstituted phenanthridine and phenanthridine-like compounds under mild and metal-free conditions.
A new and mild synthetic approach for the synthesis of 6-unsubstituted phenanthridine and phenanthridine-like compounds under metal-free conditions at room temperature has been developed. The strategy involved a tandem azide rearrangement/intramolecular annulation and oxidation reactions of biarylmethyl azide precursors to obtain the desired products in up to 99% yields with high regioselectivity.
متن کاملInhibition of purine metabolism in Ehrlich ascites carcinoma cells by phenanthridinium compounds related to ethidium bromide.
phenyl phenanthridinium bromide) has been shown to inhibit completely the incorporation of preformed purines into the nucleic acids of Ehrlich ascites carcinoma cells, but the drug does not ap preciably inhibit the incorporation of radioactive glycine into nucleic acids or proteins (4). These studies have been interpreted in terms of disrup tion of the normal relationship between intracellu lar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1956
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1956.tb01077.x